Scientist I

Job ID: req3496
Employee Type: exempt full-time
Division: Basic Science Program
Facility: Frederick: Ft Detrick
Location: USA

The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc. The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.

Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way.

PROGRAM DESCRIPTION

The Basic Science Program pursues independent, multidisciplinary research programs. Research efforts and support are an integral part of the Center for Cancer Research (CCR) at the Frederick National Laboratory for Cancer Research. This position is in the laboratory of Dr. Ruth Nussinov, a preeminent computational structural biologist.

KEY ROLES/RESPONSIBILITIES

A computationally strong candidate is required for this position at the Frederick National Laboratory for Cancer Research. This research involves simulations of oncogenic proteins aimed at discovering their activation mechanisms, the actions of their driver mutations, signaling and drug discovery, and the emerging connection to neurodevelopmental disorders. These goals make it a highly innovative project. Experience and proficiency in high performance molecular dynamics computing/simulations, extensive molecular dynamics simulations, a good grasp of fundamental physical principles and their applications in biological systems to capture the behavior of proteins in full atomic detail and at very fine temporal resolution, to decipher functional mechanisms of proteins to uncover the structural basis for disease is required.

BASIC QUALIFICATIONS

To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:

• Possession of a Doctorate degree from accredited college/university according to the Council for Higher Education Accreditation (CHEA) in a discipline related to physics, physical chemistry, or biological computations
• Foreign degrees must be evaluated for U.S. equivalency
• Strong basis and experience in biology, bioinformatics, handling large genomic, proteomics and transcriptomics data, to study the cancer-neurodevelopmental connection
• Ability to provide record of publications with first authorship papers in reputable journals is required
• Experience with molecular modeling and molecular dynamics software (e.g., CHARMM or NAMD)
• Knowledge of coding and computer languages, e.g., Python, Unix shell, C++, or Fortran
• Experience and proficiency in high performance molecular dynamics simulations
• Good grasp of fundamental physical principles and their applications in biological systems
• Strong programming skills for handling and analyzing protein systems
• Strong knowledge in protein-protein interaction networks
• Ability to obtain and maintain a security clearance

Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)

#readytowork