What if… you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies to transform human health and sustainability?

Flagship Pioneering's venture creation engine has conceived and created companies such as Moderna Therapeutics (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Sana Biotechnology (NASDAQ: SANA), Generate Biomedicines, and Tessera Therapeutics. Since its launch in 2000, Flagship has applied its unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $212 billion in aggregate value. To date, Flagship has deployed over $2.5 billion in capital toward the founding and growth of its pioneering companies alongside more than $19 billion of follow-on investments from other institutions. In 2021, Flagship Pioneering was ranked 12th globally on Fortune's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies.

The Company:

FL86, Inc. is a privately held, early-stage company developing a novel genomics platform and therapeutics for diseases with a large unmet need.

Position Summary:

Responsible for the translational validation of discovery platform targets in cell-based and in disease-relevant pharmacological models

Responsibilities:

• The successful candidate will work both independently and as part of a team to design, plan and execute high-quality biochemical, cell-based and translational assays
• Lead the development and execution of cell-based assays to assess biological signaling pathways, the biological activity of small molecules, biologics or nucleotide-based compounds
• Define tissue and disease-specific target engagement levels, establish, and run biomarker plans and translational PK/PD assessment
• Critical data analysis, attention to detail, and troubleshooting abilities
• Mentor and train research associates as needed

Qualifications:

• Ph.D. in Cell Biology, Molecular Biology, Biochemistry, Bioengineering or related discipline with > 5-8 years of experience in a biotech or pharmaceutical company (the title will be adjusted for the level of experience)
• Deep knowledge and understanding of cell biology. Proficient in experimental design, assay execution, troubleshooting, data analysis, and data interpretation
• Extensive hands-on experience in mammalian cell culture including primary cells and in handling tissues
• The ideal candidate has previous experience in cell-culture assays of metabolic diseases (e.g., Diabetes, Heart Disease, Fatty Liver Disease) and relevant cell culture lines (e.g., Myocyte, Hepatocyte, pancreatic). Experience in RNA biochemistry and structural biology, cell-based genetic manipulations (e.g., siRNA, ASO) and RNA/DNA delivery is a plus.
• Experience in the following techniques is a plus: FACS, RT-qPCR, RNA-seq, cloning, cell culture, IHC and quantitative image analysis, Meso Scale Discovery, HALO image analysis software.
• Strong written and oral presentation skills
• Execution focused, team oriented, and highly motivated

Preferred Attributes:

• Experience with translational cell-based and pharmacology models

Location: Cambridge, MA