We are seeking an experienced modeling and simulation scientist to join the DMPK group at Kymera Therapeutics. The successful candidate will develop mechanistic and translational models in several of therapeutic areas thus informing decision making and translation from discovery to early clinical development. In addition to M&S support the candidate will also represent DMPK function on project teams and guide program through lead discovery to the clinic.

In this key role, you will utilize your expertise developing and analyzing data to provide useful results and models in support of our Proteomics team. This is an ideal role for an individual that can excel while multi-tasking in a fast-paced environment. A customer-service mentality is necessary, as you will collaborate with colleagues at Kymera as you join in our efforts to rapidly advance multiple drug candidates to the clinic – promising new therapies designed to treat serious diseases.

Kymera Therapeutics is a publicly listed, clinical stage biotechnology company pioneering the field of targeted protein degradation (TPD) to bring life-changing medicines to patients that need them. Kymera's Pegasus™ TPD platform harnesses the body's natural protein recycling machinery to degrade disease-causing proteins, with a focus on undrugged nodes in validated pathways currently inaccessible with conventional therapeutics. As we work toward becoming a fully-integrated biopharmaceutical company, we are growing and strengthening organizational capabilities and evolving our culture. As a result, Kymera has been recognized by both the Boston Globe and the Boston Business Journal as one of Boston's top workplaces.

In 2023, we plan to continue to advance our leadership in TPD and enhance our capabilities to deliver on the potential of inventing a new class of protein degrader medicines for patients. Kymera is rapidly advancing four clinical stage programs in oncology and immunology, and is positioned to deliver one additional Investigational New Drug Applications (IND) annually. We are also actively advancing a broad pipeline of preclinical programs where TPD has the potential to provide a best-in-class approach, both internally and in collaboration with our partners Sanofi and Vertex Pharmaceuticals.

Responsibilities:

• Conduct PK/PD modeling of preclinical data and provide efficacious dose projections.
• Responsible for the modeling of early clinical data as appropriate.
• Design preclinical PK/PD studies in healthy and disease models.
• Develop and implement innovative, quantitative analyses and strategies for translational modeling across Discovery and Development projects.
• As a member of the DMPK team you will develop quantitative models and analyses to predict the DMPK characteristics of targeted protein degraders.
• Establish and maintain effective collaboration between biomarker, toxicology, pharmacology and DMPK scientists with the goal to predict safety margins, efficacious dose.
• Liaise with collaboration partners and CROs to generate data and models.
• Contribute to innovative and high quality publications and present data to external parties at conferences or meetings.

Qualifications:

• PhD in quantitative sciences, applied mathematics, pharmaceutical science or related field with 8 years of related work experience is required.
• Hands-on experience with relevant modeling software and programming languages including MATLAB/Simbiology, R, Python, WinNonLin/Phoenix, etc. is required.
• Strong communication skills with the ability to present to teams with diverse scientific backgrounds.
• Must have a strong understanding of Translational Sciences, DMPK, PK/PD modeling and human dose prediction and be able to give clear recommendations for the design of preclinical and clinical studies.
• Prior experience as a DMPK project team representative on a multifunctional team is required.
• Experience with QSP models is a plus.
• Ability to work in a fast-paced matrix environment.
• Passion for data driven analysis, applying innovative quantitative solutions to advance projects.

Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment. All applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, veteran status or any other applicable legally protected characteristics.